Vincent Laudet

Fish models: from zebrafish to clownfish as an inspiration to increase knowledge in cosmetics

Marine Eco-Evo-Devo unit. Okinawa Institute of Science and Technology, 1919-1 Tancha, Onna-son, Okinawa, 904-0495 Japan.

The cosmetic industry develops many new products that improve our daily life, but the safety of these products should be tested, especially in terms of endocrine disrupting activity Traditionally mammals (mouse, rats) have been used for such a purpose but fish offer very interesting alternative. Zebrafish (Danio rerio), and to a lesser extend medaka (Oryzias latipes) have emerged as invaluable model species for which elaborate technological tools and a vivid scientific community are available. However, these two species care freshwater models that cannot grasp by themselves the whole diversity of the ca. 30,000 species of teleost fishes. Several alternative models have emerged in recent years and among them the clownfish (Amphiprion ocellaris).Tthis species has the advantage of being a marine, robust, prolific fish well suited to the implementation of an experimental approach. In addition, it is possible with this fish to combine extensive laboratory analyzes with more ecological studies in the field. The clownfish is therefore becoming a model of choice for testing the environmental effects of cosmetic products such as those present in sunscreens.